science
The Science Behind Relationships; Humans Media explores the basis of our attraction, contempt, why we do what we do and to whom we do it.
We are 6 months into 2024 and I haven’t achieved all my goals yet.
We are 6 months into 2024 and I haven’t achieved all my goals yet. Let’s be true to ourselves, this is the stance of millions worldwide. We all have made our New Year resolutions and have faltered in our discourse of being consistent and true about it. To be consistent in your stance, you need clarity and focus on what you are headed towards, when the head is lost in aimless directions of what should be, we lose our sight of what we are and where we should be headed. In absolute honesty, I too was directionless in the first 6 months of my existence in 2024. To give you more insight into my journey here is my account of the first half of 2024-
By Hridya Sharma7 days ago in Humans
The Impact of Podiatry Tools and Podiatry Surgical Instruments on Medical Care
Podiatry instruments are essential for proper foot care. These specialized instruments involve different products specially made for tasks within podiatric practices, ranging from basic foot service to intricate operations.
By allex haryy7 days ago in Humans
Exploring the Best Nootropics Liquids for Mental Clarity. AI-Generated.
Do you ever feel like your cognition could be more precise or your thoughts could be more straightforward? Well, you are not the only one if this is your case. Concentration is a widespread issue that people face in today’s world. Fortunately, this is not beyond remedy, and one of the most effective ways of enhancing this is Through nootropics liquids. This blog post will discuss nootropic liquids, how they enhance clarity, and the best nootropic liquids for sale in the online market.
By James Johnsan7 days ago in Humans
Why the Desired Effect is not Achieved After Using AAV?
Adeno-associated virus (AAV) is a small non-enveloped virus, belonging to the family Parvoviridae. It was first discovered in 1965 from contaminants of adenovirus isolates. It has an icosahedral structure on the outside and a diameter of about 26 nm. Its capsid protein is composed of It is composed of three proteins: VP1, VP2 and VP3. The genome of AAV is a single-stranded linear DNA, approximately 4700 bp, including two upstream and downstream open reading frames (ORFs): Rep and Cap. They are located between 2 T-shaped inverted terminal repeats (ITRs) each consisting of 145 nucleotides. The role of ITR is to serve as the origin of viral replication and packaging signal. The Rep gene is involvedin viral replication and integration, encoding viral replication proteins, and the Cap gene is responsible for encoding the three viral capsid proteins. The natural wild-type adeno-associated virus that exists in nature has Rep and Cap genes on its genome, while the experimental AAV vector is an artificially modified plasmid based on wild adeno-associated virus and does not have Rep and Cap genes on its genome. Therefore, also called recombinant adeno-associated virus (rAAV). Unless otherwise specified, the abbreviation AAV generally refers to the modified AAV vector.
By Creative Diagnostics9 days ago in Humans
What is Procalcitonin (PCT)?
Procalcitonin (PCT) is the propeptide of calcitonin. The production of procalcitonin during infection and sepsis does not depend on calcitonin levels, but is closely related to the release of endotoxin and inflammatory mediators in bacterial infection. Traditional biological markers, clinical symptoms, and signs lack sufficient sensitivity and specificity to guide treatment decisions for infectious diseases. As a recently applied biomarker, procalcitonin is increasingly supported by increasing evidence that detecting serum procalcitonin concentration can be used to early diagnose the type of infectious pathogen, evaluate the severity of infection, guide medication, and determine prognosis. Procalcitonin has become the most useful biomarker in the management of infection and sepsis in most parts of the world.
By Creative Diagnostics9 days ago in Humans
The Mechanism of Adverse Immune Reactions of LNP-mRNA
Many clinical trials of mRNA-based drugs or vaccines have failed to successfully pass Phase I or Phase II. The reasons behind this are various, including low efficacy of candidate drugs and lower-than-expected clinical risk/treatment benefit profiles. Preclinical safety assessments aim to identify well-tolerated and efficacious LNP-mRNA formulations, and when toxicity is observed, in vivo, in vitro and ex vivo experiments aim to understand the underlying mechanisms and, ideally, improve the formulations design under development.
By CD Bioparticles9 days ago in Humans
Microfluidics Revolution: Polystyrene Particles Powering Miniaturized and Automated Immunoassays
Traditional immunoassays based on the format of 96-well microtiter plates are widely used in analytical laboratories and have become increasingly automated with the introduction of robotics technology in recent years, thereby enhancing assay throughput. Most clinical analyzers essentially operate as “stand-alone laboratories,” featuring precise, accurate, and highly reproducible programmatic liquid handling, sample addition, and washing steps. However, aside from cost, the size limitations of these automated analyzers mean they are not suitable for remote applications. Point-of-care (POC) testing traditionally revolves around nitrocellulose-based lateral flow assays, offering rapid, user-friendly solutions for explicit diagnostic needs. Unfortunately, these types of tests (e.g., pregnancy tests) are often qualitative (pregnant/not pregnant) or at most semi-quantitative. While such tests offer usability and flexibility, they typically come with increased variability, thus compromising sensitivity.
By CD Bioparticles9 days ago in Humans