CD Bioparticles
Bio
CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles and their coatings for R&D and commercialization in a wide variety of application areas including in-vitro diagnostics and biochemistry.
Stories (14/0)
The Mechanism of Adverse Immune Reactions of LNP-mRNA
Many clinical trials of mRNA-based drugs or vaccines have failed to successfully pass Phase I or Phase II. The reasons behind this are various, including low efficacy of candidate drugs and lower-than-expected clinical risk/treatment benefit profiles. Preclinical safety assessments aim to identify well-tolerated and efficacious LNP-mRNA formulations, and when toxicity is observed, in vivo, in vitro and ex vivo experiments aim to understand the underlying mechanisms and, ideally, improve the formulations design under development.
By CD Bioparticles7 days ago in Humans
Microfluidics Revolution: Polystyrene Particles Powering Miniaturized and Automated Immunoassays
Traditional immunoassays based on the format of 96-well microtiter plates are widely used in analytical laboratories and have become increasingly automated with the introduction of robotics technology in recent years, thereby enhancing assay throughput. Most clinical analyzers essentially operate as “stand-alone laboratories,” featuring precise, accurate, and highly reproducible programmatic liquid handling, sample addition, and washing steps. However, aside from cost, the size limitations of these automated analyzers mean they are not suitable for remote applications. Point-of-care (POC) testing traditionally revolves around nitrocellulose-based lateral flow assays, offering rapid, user-friendly solutions for explicit diagnostic needs. Unfortunately, these types of tests (e.g., pregnancy tests) are often qualitative (pregnant/not pregnant) or at most semi-quantitative. While such tests offer usability and flexibility, they typically come with increased variability, thus compromising sensitivity.
By CD Bioparticles7 days ago in Humans
Colored Polystyrene Particles in Developing Rapid and Affordable Point-of-Care Diagnostics
What is POCT? POCT (Point-of-Care Testing) refers to clinical and bedside testing conducted in close proximity to patients. It is often not performed by clinical laboratory personnel. POCT holds significant importance in disease prevention, etiology determination, prognosis, enhancing treatment outcomes, and reducing healthcare expenses. It meets clinical testing needs across various healthcare settings. POCT serves as a complement to traditional laboratory testing methods. It is characterized by short testing times, spatial flexibility, and simple operation.
By CD Bioparticlesabout a month ago in Humans
Progress in the Development of Targeted Anti-Tumor Antibody-Drug Conjugates
Antibody-drug conjugates (ADCs) are conjugated products of monoclonal antibodies (mAbs) and cytotoxic small molecules. In tumor treatment, although monoclonal antibodies have good targeting properties, most of them target extracellular or cell surface antigens, have weak anti-tumor activity, have limited therapeutic effect on solid tumors, and are more likely to develop drug resistance; conventional anti-tumor chemotherapy Although drugs have high anti-tumor cell activity, they lack targeting and often accidentally damage normal cells in the body, causing serious side effects. Antibody-drug conjugates complement each other perfectly, combining the high specificity of antibodies with the high toxicity of cytotoxic drugs to tumors. They can specifically kill tumor cells without damaging normal tissue cells, and are clinically highly effective and low-cost.
By CD Bioparticles2 months ago in Humans
Exploring Dyed Polystyrene Latex Particles Enhancing Immunoassays and Beyond
What are Dyed Polystyrene Latex Particles? Polystyrene particles (PSP) are commercially available in different sizes, ranging from 15 nanometers to several micrometers, with narrow size distributions and various surface chemistries. Additionally, polystyrene is generally considered inert and nontoxic, making it safe for use in a variety of biological assays. Dyed polystyrene latex particles or colored latex beads have excellent multiplexing capability and have the following characteristics: a. Diversity, that is, diversity of particle size, color, and color depth; b. High labeling efficiency; c. Stability, it has good chemical and physical properties in aqueous solution. These characteristics provide a strong guarantee for the rapid development and application of colored latex particles in medical diagnostic technology.
By CD Bioparticles2 months ago in Humans
Progress in the Development of Targeted Anti-Tumor Antibody-Drug Conjugates
Antibody-drug conjugates (ADCs) are conjugated products of monoclonal antibodies (mAbs) and cytotoxic small molecules. In tumor treatment, although monoclonal antibodies have good targeting properties, most of them target extracellular or cell surface antigens, have weak anti-tumor activity, have limited therapeutic effect on solid tumors, and are more likely to develop drug resistance; conventional anti-tumor chemotherapy Although drugs have high anti-tumor cell activity, they lack targeting and often accidentally damage normal cells in the body, causing serious side effects. Antibody-drug conjugates complement each other perfectly, combining the high specificity of antibodies with the high toxicity of cytotoxic drugs to tumors. They can specifically kill tumor cells without damaging normal tissue cells, and are clinically highly effective and low-cost.
By CD Bioparticles3 months ago in Humans
Exploring Dyed Polystyrene Latex Particles Enhancing Immunoassays and Beyond
What are Dyed Polystyrene Latex Particles? Polystyrene particles (PSP) are commercially available in different sizes, ranging from 15 nanometers to several micrometers, with narrow size distributions and various surface chemistries. Additionally, polystyrene is generally considered inert and nontoxic, making it safe for use in a variety of biological assays. Dyed polystyrene latex particles or colored latex beads have excellent multiplexing capability and have the following characteristics: a. Diversity, that is, diversity of particle size, color, and color depth; b. High labeling efficiency; c. Stability, it has good chemical and physical properties in aqueous solution. These characteristics provide a strong guarantee for the rapid development and application of colored latex particles in medical diagnostic technology.
By CD Bioparticles3 months ago in Humans
Zeta Potential: A Fundamental Measure for Colloidal Behavior
What is Zeta Potential? Zeta potential (ZP) is a physical property exhibited by any particle in a suspension, macromolecule or material surface. ZP is an analytical technique used to determine the surface charge of nanoparticles in colloidal solutions. The surface of a charged particle attracts and binds firmly to a thin layer of opposite charge, forming a thin layer of liquid called the Stern layer; as the particle diffuses in the solution, it will be replaced by a thin layer of loosely bound ions. The outer diffusion layer is involved, resulting in an electric double layer (Figure 1). Zp is named after the potential of the electric double layer and is determined by measuring the speed of charged particles moving through the sample solution toward the electrode in the presence of an external electric field. ZP values are typically in the range of +100 to −100 mV. The magnitude of the ZP gives a prediction of colloidal stability. The ZP of NPs with values >+25 mV or <−25 mV is generally highly stable. Lower dispersion ZP values can lead to aggregation, coagulation or flocculation due to van der Waals attraction between particles. Zeta potential can be used to optimize the formulation of suspensions, emulsions and protein solutions, predict interactions with surfaces, and optimize the formation of films and coatings. Understanding zeta potential can reduce the time required to produce pilot formulations. It can also be used as an aid in forecasting long-term stability.
By CD Bioparticles3 months ago in Humans
Application of Carrageenan Hydrogel in Biomedical Field
Hydrogel is a three-dimensional network of hydrophilic polymers that swells in water without dissolving. Because the polymer contains a large number of hydrophilic groups, the hydrogel can absorb and lock a large amount of water. After absorbing water, the hydrogel network can maintain its original shape without being destroyed. Hydrogels are widely used in tissue engineering, drug delivery, biosensing, etc. due to their simple preparation, strong tunability of mechanical properties, good biocompatibility, and elasticity and softness that are very similar to most tissues and extracellular matrices of the human body. The field is developing rapidly. Depending on the source from which the hydrogel is prepared, hydrogels can be divided into natural hydrogels and synthetic hydrogels. Due to society’s demand for sustainable products, hydrogels derived from natural materials, especially those from renewable resources, have attracted attention. Among renewable resources, polysaccharides have become the most promising hydrogel precursors due to their inherent hydrophilicity and biodegradability. Carrageenan is a sulfated polysaccharide extracted from red algae. It is composed of alternating units of D-galactose and 3,6-anhydrogalactose linked by α-1,3 and β-1,4-glycosidic bonds. Carrageenan is divided into 6 basic forms according to its sulfate content, extraction source and solubility, namely: k-carrageenan, t-carrageenan, λ-carrageenan, μ-carrageenan, ν-carrageenan and θ-carrageenan. K-carrageenan, t-carrageenan and λ-carrageenan have important commercial value due to their gelling and viscoelastic properties. t-carrageenan and k-carrageenan have the ability to form hydrogels and form a three-dimensional double helix network through cross-linking of adjacent sulfate groups. However, the sulfate groups of λ-carrageenan do not cross-link and therefore do not form a gel. The presence of hydroxyl/sulfate groups on carrageenan makes it easy to undergo physical or chemical cross-linking, giving carrageenan better physical and chemical properties, new special functions and characteristics. Carrageenan hydrogel has been widely used in biomedicine and tissue engineering fields, such as drug delivery, wound dressings, tissue engineering scaffold materials, etc. This article reviews several types of carrageenan hydrogels and their application progress in the biomedical field.
By CD Bioparticles5 months ago in Humans
Illuminating the World of Plasmonic Nanoparticles: Unveiling the Mystery of Plasmons
Surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) are two key surface plasmon technologies that ultimately enable single-molecule-level chemical and biological sensors. Due to the tremendous progress in solution-based synthesis methods, plasmonic nanoparticles with various complex shapes (e.g., spheres, rods, and prisms) have been widely used for surface plasmon resonance and surface-enhanced Raman scattering sensing. Localized surface plasmon resonance (LSPR) around plasmonic nanoparticles enables very high SERS enhancement and SPR sensitivity.
By CD Bioparticles5 months ago in Humans
Micelle vs Liposome
Micelles refer to molecularly ordered aggregates that begin to form in large quantities after the surfactant concentration reaches a certain value in an aqueous solution. In micelles, the hydrophobic groups of surfactant molecules aggregate to form the core of the micelle, and the hydrophilic polar groups form the outer layer of the micelle. Liposomes are an artificial membrane. In the water, the hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends into the air. After stirring, a spherical liposome with a double layer of lipid molecules is formed, with a diameter ranging from 25 to 1000 nm.
By CD Bioparticles6 months ago in Education
How to Prepare Sodium Alginate Microspheres with Controllable Particle Size
Sodium alginate is a sodium salt of polyanionic alginic acid. It is a natural high molecular polysaccharide polymer extracted from natural brown algae. It has the advantages of wide source, low price, good biocompatibility, and degradability. Contains multiple hydroxyl and carboxyl functional groups, so it can react with a variety of divalent or trivalent cations to form hydrogels, and is widely used in biomedical fields such as cell engineering, drug sustained release, and medical dressings. When sodium alginate microspheres are applied to the fields of drug loading, controlled release, and interventional therapy, the control of particle size and morphology of the microspheres is particularly important. For large-sized microspheres ranging from hundreds of microns to millimeters, microspheres with a particle size of 130-1600 μm can be produced by using electrostatic spraying technology by controlling the relevant parameters of electrospraying. This method can achieve particle size control, but the productivity is low, and it is only suitable for Experimental research; spray-drying method can obtain microspheres with narrow particle size distribution and less than 2 μm, but the production of drug-loaded microspheres by this method has disadvantages such as high cost, limited by viscosity, thermal instability and low productivity, and it is difficult for production equipment There are certain requirements. Considering that the concentration of sodium alginate solution and the concentration of calcium chloride have an important influence on the gel properties of sodium alginate, sodium alginate microspheres can be prepared by emulsification and cross-linking method with simple operation, and then explore the microsphere morphology of different factors. The aim is to obtain microspheres with monodispersity, controllable particle size, narrow particle size distribution and good shape.
By CD Bioparticles11 months ago in Humans
