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Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents.
Stories (15/0)
Challenges in Malaria Vaccine Development
Introduction Malaria is caused by infection with Plasmodium parasites. Plasmodium belongs to unicellular eukaryote, and the Plasmodium that infects human body mainly comprises 5 kinds: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi. Among them, Plasmodium falciparum and Plasmodium vivax are the most widespread in the global epidemic area, and Plasmodium falciparum is the most important species that causes the death of malaria patients. The life cycle of Plasmodium is complex and mainly includes three stages: infrared stage, red inner stage and mosquito stage. Among them, both the red inner stage and the infrared stage of Plasmodium carry out asexual development and reproduction in the human body, while the mosquito stage carries out sexual reproduction and spore proliferation and development in Anopheles mosquitoes. In order to control and eliminate malaria, corresponding candidate vaccines are mainly designed for the three stages of the life cycle of Plasmodium, in order to block the life cycle of Plasmodium from multiple links. The infrared phase is the initial stage of malaria parasite infection, and it is also the main period leading to the recurrence of malaria. Blocking the development of malaria parasites in the infrared phase can control the infection and resurgence of malaria parasites from the source. Therefore, the infrared phase vaccine is also called malaria preventive; red-phase vaccines mainly reduce clinical morbidity and mortality, so they are also called malaria therapeutic vaccines; mosquito-phase vaccines mainly block the transmission of malaria parasites, so they are also called transmission-blocking vaccines.
By Creative Diagnostics12 months ago in Humans
What is Antibody-Dependent Enhancement
After the host is infected by the virus, the immune system can generate a corresponding immune response. Antibodies specific to viral surface proteins produced at this time can often prevent the virus from adhering to the surface of host cells, making it incapable of infecting cells. However, in some cases, antibodies play the opposite role during viral infection, they assist the virus to enter the target cells and increase the infection rate, this phenomenon is antibody-dependent enhancement (ADE).
By Creative Diagnosticsabout a year ago in Humans
Breakthrough Ideas for Parkinson’s Disease Treatment
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by bilateral motor (eg, bradykinesia, resting tremor, postural instability, rigidity) and nonmotor (eg, memory loss, depression) disability. About 10 million people worldwide suffer from Parkinson’s disease. Current PD treatments are limited to motor symptom management, such as dopamine replacement therapy or enhancing the activity of remaining dopaminergic neurons. There are no known treatments that slow progression or prevent the onset of the disease. Furthermore, PD patients are growing at an unprecedented rate and are expected to increase to 17.5 million by 2040. Although aging remains a major risk factor for PD, more than 20 genes have been found to be associated with PD onset and progression, suggesting therapeutic potential for Parkinson’s disease.
By Creative Diagnosticsabout a year ago in Humans